Three new derivatives of 2-phenylquinoline having an (2-aminoethyl) aminomethyl group in 7-, 6-, or 4′-(para position of 2-phenyl ring) positions of aromatic system have been prepared. The antitumor activity of these compounds together with 8-or 4-substituted isomers against the HeLa cell is in the order of 8-> 7-> 4-≈ 6-≈ 4′-substituted ones, which is almost in good agreement with that of DNA-binding ability evaluated by means of DNA- ...
