Universal method for trimethylsilylation of acetylenic alcohols and glycols

M Demina, A Velikanov, A Medvedeva, L Larina…

文献索引：Demina, Maria; Velikanov, Andrey; Medvedeva, Alevtina; Larina, Lyudmila; Voronkov, Mikhail Journal of Organometallic Chemistry, 1998 , vol. 553, # 1-2 p. 129 - 133

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被引用次数: 16

摘要

A highly convenient universal method for trimethylsilylation of acetylenic alcohols and glycols via treatment by hexamethyldisilazane in the presence of benzoic acid sulphimide as a catalyst has been developed. The rate of trimethylsilylation of acetylenic alcohols is reduced from primary to secondary and to tertiary alcohols accordingly, as well as with the decreasing of hydroxyl nucleophylicity. The toxicity of trimethylsilyl acetylenic ethers, ...