Neurotropic and psychotropic agents. LXIII. 7-Methoxy-10-(4-methylpiperazino) dibenzo [b, f] thiepin and its 10, 11-dihydro derivative

V Bártl, J Metyšová, J Metyš, J Němec…

文献索引：Bartl; Metysova; Metys; et al. Collection of Czechoslovak Chemical Communications, 1973 , vol. 38, # 8 p. 2301 - 2306

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被引用次数: 6

摘要

2-(3-Methoxyphenylthio) benzoic acid (VII) was converted in five steps to 7-methoxy-llH- dibenzo [b, fjthiepin-10-one (11). Reaction with I-methylpiperazine and titanium tetrachloride yielded 7-methoxy-1O-(4-methylplperazino) dibenzo [b, fjthiepin (V) which was reduced by diborane to the 10, 11-dihydro derivative I. This compound has a relatively high antihistamine activity while it is a weak central depressant and cataleptic. The enamine V ...