Molecular Design of Organic Superbases, Azacalix [3](2, 6) pyridines: Catalysts for 1, 2-and 1, 4-Additions

…, J Kuwabara, A Taketoshi, T Kanbara

文献索引：Uchida, Natsuko; Taketoshi, Ayako; Kuwabara, Junpei; Yamamoto, Toshihide; Inoue, Yoshiaki; Watanabe, Yu; Kanbara, Takaki Organic Letters, 2010 , vol. 12, # 22 p. 5242 - 5245

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被引用次数: 11

摘要

The molecular design, characteristics, and catalytic activity of macrocyclic amino compounds, azacalix [3](2, 6) pyridine derivatives, were studied. The introduction of an electron-donating group on the pyridine moiety and bridging amino phenyl group enabled the enhancement of the basicity of azacalix [3](2, 6) pyridine up to p K BH+= 29.5 in CD3CN. These derivatives were shown to be efficient catalysts for 1, 4-addition reactions of ...