Mechanistic studies on thiazolidine formation in aldehyde/cysteamine model systems

TC Huang, LZ Huang, CT Ho

文献索引：Huang, Tzou-Chi; Huang, Lee-Zen; Ho, Chi-Tang Journal of Agricultural and Food Chemistry, 1998 , vol. 46, # 1 p. 224 - 227

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被引用次数: 23

摘要

A mechanism was proposed to elucidate the formation of a thiazolidine in aldehyde/cysteamine model systems. Buffer dramatically promotes thiazolidine formation from formaldehyde and cysteamine. Phosphate tends to stabilize the primary carbocation formed, and this may lead to completion of the cyclization by attack of the amino nitrogen on the activated carbon. Protic solvent, by removing the water molecule, further enhances ...