The NiCEST approach: nickel (II) paraCEST MRI contrast agents

AO Olatunde, SJ Dorazio, JA Spernyak…

文献索引：Olatunde, Abiola O.; Dorazio, Sarina J.; Spernyak, Joseph A.; Morrow, Janet R. Journal of the American Chemical Society, 2012 , vol. 134, # 45 p. 18503 - 18505

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被引用次数: 38

摘要

Paramagnetic Ni (II) complexes are shown here to form paraCEST MRI contrast agents (paraCEST= paramagnetic chemical exchange saturation transfer; NiCEST= Ni (II) based CEST agents). Three azamacrocycles with amide pendent groups bind Ni (II) to form stable NiCEST contrast agents including 1, 4, 7-tris (carbamoylmethyl)-1, 4, 7-triazacyclononane (L1), 1, 4, 8, 11-tetrakis (carbamoylmethyl)-1, 4, 8, 11-tetraazacyclotetradecane (L2), and 7 ...