New nonsteroidal antiinflammatory agent. 2-Substituted 5-or 6-benzothiazoleacetic acids and their derivatives

J Wada, T Suzuki, M Iwasaki, H Miyamatsu…

文献索引：Wada,J. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 930 - 934

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被引用次数: 17

摘要

Synthesis of 34 2-substituted benzothiazole compounds with an acetic acid function at the 5 or 6 position was carried out and their antiinflammatory activity was investigated. It was found that the presence of an acetic acid function was important for antiinflammatory activity and also that 2-substituted 5-benzothiazoleacetic acids (6) were better than 2-substituted 6- benzothiazoleacetic acids (7) in antiinflammatory activity