Design and synthesis of novel CCR3 antagonists

…, JH Hogg, J Collier, RS Wilhelm, C Soderberg

文献索引：Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600

全文：HTML全文

被引用次数: 13

摘要

As part of our investigation into the development of potent CCR3 antagonists, a series of piperidine analogues was designed and prepared. Exploration of the piperidine core examined both the basicity and the location of a nitrogen, as well as conformational variants. The bicyclo-piperidine 24c was found to be the most potent inhibitor of CCR3 with an IC50 of 0.0082 μM in the binding assay and 0.0024 μM in the chemotaxis assay.

2597-56-0

2-甲氧基-4-硝基苯甲酸

13684-28-1

2-羟基-4-硝基苯甲酸甲酯

查看详情

~95%

查看详情

~96%

查看详情

查看详情

查看详情

~96%

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

~83%

查看详情

Conformational properties of O-alkylated benzamides

[Prabhakaran, Panchami; Azzarito, Valeria; Jacobs, Tia; Hardie, Michaele J.; Kilner, Colin A.; Edwards, Thomas A.; Warriner, Stuart L.; Wilson, Andrew J. Tetrahedron, 2012 , vol. 68, # 23 p. 4485 - 4491]

Specific Detection and Imaging of Enzyme Activity by Signal?...

[Matsuo, Kazuya; Kamada, Rui; Mizusawa, Keigo; Imai, Hirohiko; Takayama, Yuki; Narazaki, Michiko; Matsuda, Tetsuya; Takaoka, Yousuke; Hamachi, Itaru Chemistry - A European Journal, 2013 , vol. 19, # 38 p. 12875 - 12883]

Synthesis, structure–activity relationship, and p210 bcr-abl...

[Kaur, Gurmeet; Narayanan, Ven L.; Risbood, Prabhakar A.; Hollingshead, Melinda G.; Stinson, Sherman F.; Varma, Ravi K.; Sausville, Edward A. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1749 - 1761]