A new approach to rapid parallel development of four neurokinin antagonists. Part 4. Synthesis of ZD2249 methoxy sulfoxide

…, WO Moss, PM Murray, MJ Welham…

文献索引：Parker, Jeremy S.; Smith, Neil A.; Welham, Matthew J.; Moss, William O. Organic Process Research and Development, 2004 , vol. 8, # 1 p. 45 - 50

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被引用次数: 37

摘要

The manufacture of ZD2249 methoxy sulfoxide (1) using a new project approach is described. Research department processes were scaled up to 100 L if process safety and robustness were not compromised; other factors were treated according to the new approach. Using this strategy, we were able to manufacture a key intermediate on sufficient scale to support delivery of 1 kg quantities of bulk drug within 6 months of the start of lab ...