Organic letters

Synthesis of novel imidazo [1, 2-a] pyridines with potent activity against herpesviruses

KS Gudmundsson, BA Johns

文献索引：Gudmundsson, Kristjan S.; Johns, Brian A. Organic Letters, 2003 , vol. 5, # 8 p. 1369 - 1372

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被引用次数: 72

摘要

Synthesis of a novel imidazopyridine with potent activity against herpes simplex viruses is presented. Several synthetic approaches that describe the introduction of a C-3 pyrimidine substituent on the imidazopyridine core via construction of the pyrimidine or Stille coupling are outlined. Methodology for efficient installation of C-8 amine substituents was developed. The outlined strategies provide a high-yielding, scalable route that is amenable to rapid ...