Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands

…, AR Miller, EA Misener, C Montrose-Rafizadeh…

文献索引：Warshawsky, Alan M.; Alt, Charles A.; Brozinick, Joseph T.; Harkness, Allen R.; Hawkins, Eric D.; Henry, James R.; Matthews, Donald P.; Miller, Anne R.; Misener, Elizabeth A.; Montrose-Rafizadeh, Chahrzad; Rhodes, Gary A.; Shen, Quanrong; Vance, Jennifer A.; Udodong, Uko E.; Wang, Minmin; Zhang, Tony Y.; Zink, Richard W. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6328 - 6333

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被引用次数: 7

摘要

PPAR ligands with varied subtype selectivity have been synthesized using an achiral aminomethyl dihydrocinnamate template. Several compounds in this series have demonstrated potent plasma glucose and triglyceride lowering capability in rodent models of type 2 diabetes.