Imidazoline-binding domains on monoamine oxidase B and subpopulations of enzyme

…, V Bakthavachalam, J Lesnick, JR Jasper…

文献索引：Raddatz, Rita; Savic, Sandra L.; Bakthavachalam, Venkatesalu; Lesnick, John; Jasper, Jeffrey R.; McGrath, Christopher R.; Parini, Angelo; Lanier, Stephen M. Journal of Pharmacology and Experimental Therapeutics, 2000 , vol. 292, # 3 p. 1135 - 1145

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被引用次数: 34

摘要

Abstract A series of phenoxy-substituted methylimidazoline derivatives were synthesized and used to define the ligand recognition properties of the imidazoline-binding domain (IBD) on monoamine oxidase (MAO)-B and its role in substrate processing. The rank order of potency for selected compounds in competitive binding studies with the imidazoline [3 H] idazoxan was different from that in enzyme activity assays, suggesting that the IBD and the ...