Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents

T Wang, M Sepulveda, P Gonzales, S Gately

文献索引：Wang, Tong; Sepulveda, Mario; Gonzales, Paul; Gately, Stephen Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 17 p. 4790 - 4793

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被引用次数: 8

摘要

Abstract A series of benzimidazole based HDAC inhibitors have been rationally designed, synthesized and screened. The SAR of this new chemotype is described. The lead compound, 11e, showed strong activity in several cellular assays and demonstrated in vivo efficacy in mouse xenograft pancreatic cancer models.