Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers

…, C Prakash, DM Roden, DJ Snyders

文献索引：Yang; Prakash; Roden; Snyders British Journal of Pharmacology, 1995 , vol. 115, # 2 p. 267 - 274

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被引用次数: 60

摘要

1 The cardiac toxicity of racemic terfenadine (marked QT prolongation and polymorphic ventricular arrhythmias) is probably due to potassium channel blockade. To test whether one of its enantiomers would be a less efficient potassium channel blocker, we compared the mechanism of action of the racemate with that of the individual enantiomers. 2 We synthesized the individual enantiomers of terfenadine and examined under whole cell ...