Tetrahedron letters

Copper catalyzed magnesium-Barbier reaction for γ-selective alkyl–allyl coupling

E Erdik, M Koçoğlu

文献索引：Erdik, Ender; Kocoglu, Melike Tetrahedron Letters, 2007 , vol. 48, # 24 p. 4211 - 4214

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被引用次数: 9

摘要

CuCN catalyzed alkyl–allyl coupling under magnesium-Barbier conditions occurs regioselectively and affords predominantly the γ-products in good to high yields. This one- pot CuCN catalyzed reaction utilising Mg, an alkyl halide and an allylic substrate in THF at room temperature provides an easy alternative to the classical CuCN catalyzed γ-allylation of alkyl Grignard reagents.