Discovery of inhibitors of Burkholderia pseudomallei methionine aminopeptidase with antibacterial activity

…, CG Campos, MW Henderson, Z Zhang…

文献索引：Bhat, Shridhar; Shim, Joong Sup; Zhang, Feiran; Chong, Curtis Robert; Liu, Jun O. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 15 p. 2979 - 2992

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被引用次数: 6

摘要

Evaluation of a series of MetAP inhibitors in an in vitro enzyme activity assay led to the first identification of potent molecules that show significant growth inhibition against Burkholderia pseudomallei. Nitroxoline analogues show excellent inhibition potency in the BpMetAP1