Abstract A series of 2-(α-hydroxyacetyl) pyridine thiosemicarbazones was synthesized as potential antimalarial and antibacterial agents. Their synthesis was achieved by the condensation of N 4-mono-or N 4, N 4-disubstituted thiosemicarbazides with 2-(α- hydroxyacetyl) pyridine. The latter was prepared by selective bromine oxidation of (2- pyridinyl)-1, 2-ethanediol. The new compounds show potent inhibitory activity against ...
