Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block

SJA Grove, J Kaur, AW Muir, E Pow, GJ Tarver…

文献索引：Grove, Simon J.A.; Kaur, Jasmit; Muir, Alan W.; Pow, Eleanor; Tarver, Gary J.; Zhang, Ming-Qiang Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 193 - 196

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被引用次数: 20

摘要

A series of oxyanilinium-based AChE inhibitors have been synthesised and tested for the reversal of vecuronium-induced neuromuscular block. Several compounds, for example 2- hydroxy-and 2-methoxy-N, N-dimethyl-N-allylanilinium bromide (3 and 6) showed comparable reversal potencies to edrophonium and clean in vivo cardiovascular profiles.