Chemistry and antiinflammatory activities of prodolic acid and related 1, 3, 4, 9-tetrahydropyrano [3, 4-b] indole-1-alkanoic acids. 1

CA Demerson, LG Humber, TA Dobson…

文献索引：Demerson,C.A. et al. Journal of Medicinal Chemistry, 1975 , vol. 18, p. 189 - 191

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被引用次数: 29

摘要

Chemistry. The synthetic route usedl involved the acid-catalyzed (p-TSA or Pz05) intramolecular alkylation at the 2 position of the indole nucleus by a hemiketal 111, or a derived oxonium ion intermediate IV, formed in situ from the reaction of an indole-3-ethanol (tryptophol) I and a keto ester RlCORz I1 (see Table I for definitions of R1 and Rz). The 1, 3, 4, 9-tetrahydropyrano [3, 4-b] indole-l-alka-noic acid esters obtained from this reaction ...