Novel substituted quinoxaline 1, 4-dioxides with in vitro antimycobacterial and anticandida activity

…, G Paglietti, MER Nikookar, P Sanna, L Sechi…

文献索引：Carta, Antonio; Paglietti, Giuseppe; Rahbar Nikookar, Mohammad E; Sanna, Paolo; Sechi, Leonardo; Zanetti, Stefania European Journal of Medicinal Chemistry, 2002 , vol. 37, # 5 p. 355 - 366

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被引用次数: 104

摘要

Thirty-six 6 (7)-substituted-3-methyl-or 3-halogenomethyl-2-phenylthio–phenylsulphonyl– chloro-quinoxaline 1, 4-dioxides belonging to series 3–6 were synthesised and submitted to a preliminary in vitro evaluation for antimycobacterial, anticandida and antibacterial activities. Antitubercular screening showed a generally good activity of 3-methyl-2- phenylthioquinoxaline 1, 4-dioxides (3d, e, h–j) against Mycobacterium tuberculosis, and ...