New acetylenic furan derivatives: synthesis and anti-inflammatory activity

…, CW Nogueira, RB Panatieri, AL Braga, CC Silveira…

文献索引：Zeni, Gilson; Luedtke, Diogo S.; Nogueira, Cristina W.; Panatieri, Rodrigo B.; Braga, Antonio L.; Silveira, Claudio C.; Stefani, Helio A.; Rocha, Joao B.T. Tetrahedron Letters, 2001 , vol. 42, # 51 p. 8927 - 8930

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被引用次数: 59

摘要

A series of acetylenic furan derivatives have been synthesized via Pd-catalyzed coupling reactions of 2-(alkyltelluro) furan with several terminal alkynes. These compounds showed good anti-inflammatory activity in the carrageenin-induced rat paw edema assay. This represents a new and efficient method for the synthesis of pharmacologically active compounds.