Journal of the American Chemical Society

Synthesis and study of a 6-amino-5-oxo-3H, 5H-uracil and derivatives. The structure of an intermediate proposed in mechanisms of flavin and pterin oxygenases

A Wessiak, TC Bruice

文献索引：Wessiak; Bruice Journal of the American Chemical Society, 1983 , vol. 105, # 14 p. 4809 - 4825

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被引用次数: 22

摘要

Abstract: The synthesis of 6 4 [2-(dimethylamino)-4, 5-dimethylphenyl] methylamino]-3- methyl-5-oxo-3H, 5H-uracil (12b) has been carried out by peracid oxidation of the N5- quaternized 3-methyllumiflavi11, 10b (Scheme V), and the preparation of the 5-diazo-3H, 5H- uracils (4a-c) and 5-oxo-3H, SH-uracil hydrazones (58-c) has been carried out as shown in Scheme IV. The structures of these compounds have been firmly established by 15N and ...