Canadian Journal of Chemistry

The reaction of 1, 2, 3-thiadiazoles with base. I. A new route to 1-alkynyl thioethers

R Raap, RG Micetich

文献索引：Raap,R.; Micetich,R.G. Canadian Journal of Chemistry, 1968 , vol. 46, p. 1057 - 1063

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被引用次数: 82

摘要

The reaction between 1, 2, 3-thiadiazoles, unsubstituted in the 5-position, and a strong base such as an organolithium compound, sodamide, sodium methylsulfinyl carbanion, or potassium t-butoxide results in cleavage of the thiadiazole ring system with evolution of nitrogen and formation of alkalimetal alkynethiolate. Subsequent addition of an alkyl or acyl halide to the reaction mixture produces 1-alkynyl thioethers. 4-(5-Phenyl-1, 2, 3- ...