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Synthesis of possible metabolites of chlorpromazine. II. 3??, 8??and 9??hydroxychlorpromazine

EA Nodiff, N Oda, T Hayazaki, S Ina…

文献索引:Nodiff,E.A. et al. Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177

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被引用次数: 10

摘要

Abstract The title compounds have been prepared as analytical standards for the identification of chlorpromazine metabolites in biological materials. Unequivocal structural proof of key compounds was accomplished by using at least two unrelated syntheses for each one. Resistance of some phenothiazines to preparation via classic Smiles rearrangement is discussed. More examples are offered of halogen-induced Smiles ...

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