Potent and selective isophthalamide S 2 hydroxyethylamine inhibitors of BACE1

…, TE Benson, MJ Bienkowski, TL Emmons…

文献索引：Kortum, Steven W.; Benson, Timothy E.; Bienkowski, Michael J.; Emmons, Thomas L.; Prince, D. Bryan; Paddock, Donna J.; Tomasselli, Alfredo G.; Moon, Joseph B.; LaBorde, Alice; TenBrink, Ruth E. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3378 - 3383

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被引用次数: 34

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D. ... The design and synthesis of a novel series of potent ...