Anxiolytic activity of analogues of 4-benzylamino-2-methyl-7H-pyrrolo [2, 3-d] pyrimidines

…, M Sznaidman, GT Pollard, LM Beauchamp…

文献索引：Meade, Eric A.; Sznaidman, Marcos; Pollard, Gerald T.; Beauchamp, Lilia M.; Howard, James L. European Journal of Medicinal Chemistry, 1998 , vol. 33, # 5 p. 363 - 374

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被引用次数: 19

摘要

An extensive series of analogues of the lead anxiolytic 4-benzylamino-2-methylpyrrolo [2, 3- d] pyrimidine 1 was synthesized and evaluated in the Geller-Seifter conflict test for anxiolytic activity to discover a less toxic derivative. Analysis of the SAR revealed that the most potent compounds were those with meta substituents on the benzylamino ring. In this group the most promising derivatives were 4-[bis (3, 5-dimethylamino)] benzylamino-2-methyl-7H- ...