Activation of 1, 2??Keto Esters with Takemoto's Catalyst toward Michael Addition to Nitroalkenes

…, T Constantieux, D Bonne, J Rodriguez

文献索引：Raimondi, Wilfried; Basle, Olivier; Constantieux, Thierry; Bonne, Damien; Rodriguez, Jean Advanced Synthesis and Catalysis, 2012 , vol. 354, # 4 p. 563 - 568

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被引用次数: 20

摘要

In continuation to our ongoing studies on conjugate additions to nitroolefins,8 we became interested in the challenging reactivity of α-keto esters as pronucleophiles in organocatalyzed Michael reactions since no example of such a transformation has been reported so far.9,10 Our own interest in the activation of 1,2-dicarbonyl compounds11 and the very recent report from Terada and co-workers on an unprecedented enantioselective organocatalyzed amination of α-keto ...