Tetrahedron Letters

Efficient chromatography-free synthesis of the oxy-analogue of fingolimod

A Zivkovic, H Stark

文献索引：Zivkovic, Aleksandra; Stark, Holger Tetrahedron Letters, 2010 , vol. 51, # 29 p. 3769 - 3771

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被引用次数: 7

摘要

Fingolimod (FTY720) and its analogue derivatives are not only promising therapeutics in sphingolipid signaling but also valuable tools for understanding the roles of sphingolipids in (patho) physiological conditions. A practical method for the synthesis of the ether analogue of FTY720 is described. Our final synthetic approach allows high yield and efficient synthesis of O-FTY in only four steps without chromatographic purifications.