The use of protected amino acid fluorides as activated forms of the N-protected R-amino acids both for solutionphase1 and for solid-phase synthesis2 of peptides has recently acquired a remarkable expansion. 3 The main reasons for their success may be ascribed to their unique properties, namely,(i) their inherent stability after purification even in the presence of tert-butyl-based protecting groups,(ii) the scarce or even absent oxazolone ...
