Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors

FM Leonik, RL Papke, NA Horenstein

文献索引：Leonik, Fedra M.; Papke, Roger L.; Horenstein, Nicole A. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1520 - 1522

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被引用次数: 16

摘要

The α7 subtype of the neuronal nicotinic acetylcholine receptors (nAChRs) was targeted for the design of selective agonists deriving from the quinuclidine scaffold. Arylidene groups at the 3-position and N-methyl quinuclidine were found to be selective agonists with EC50s of 1.5 and 40μM, respectively.