Tetrahedron letters

Synthesis of novel cationic cardiolipin analogues for the optimal delivery of therapeutic agents

K Kasireddy, MU Ahmad, SM Ali, I Ahmad

文献索引：Kasireddy, Krishnudu; Ahmad, Moghis U.; Ali, Shoukath M.; Ahmad, Imran Tetrahedron Letters, 2004 , vol. 45, # 13 p. 2743 - 2746

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被引用次数: 14

摘要

A novel approach was developed to synthesize cardiolipin analogues containing two quaternary ammonium groups with tetraalkyl chain retaining 'glycerol'moiety, the central core of the molecule. The analogues were synthesized with or without spacer and/or lipid chain length with saturation to tailor lipid-based formulations of therapeutic agents for optimal delivery to target sites.