Rhenium-Catalyzed Regioselective Synthesis of Multisubstituted Pyridines from β-Enamino Ketones and Alkynes via C–C Bond Cleavage

…, K Okamoto, M Murakoso, Y Kuninobu, K Takai

文献索引：Yamamoto, Shun-Ichi; Okamoto, Kana; Murakoso, Makiko; Kuninobu, Yoichiro; Takai, Kazuhiko Organic Letters, 2012 , vol. 14, # 12 p. 3182 - 3185

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被引用次数: 39

摘要

A new method is described for the regioselective synthesis of multisubstituted pyridine derivatives. Treatment of N-acetyl β-enamino ketones with alkynes in the presence of the rhenium catalyst, Re2 (CO) 10, gives multisubstituted pyridines regioselectively. In this reaction, the N-acetyl moieties are important for the selective formation of the multisubstituted pyridines. This reaction proceeds via insertion of alkynes into a carbon– ...