Tetrahedron Letters

Total synthesis and structural confirmation of (±)-cuevaene A

PGE Craven, RJK Taylor

文献索引：Craven, Philip G.E.; Taylor, Richard J.K. Tetrahedron Letters, 2012 , vol. 53, # 40 p. 5422 - 5425

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被引用次数: 7

摘要

The total synthesis and structural reassignment of cuevaene A have been completed. The key synthetic steps in the total synthesis included a base-promoted double conjugate addition and further elaboration to generate the tricyclic core structure, followed by construction of the trienoic acid side chain. Detailed comparison of proton and carbon NMR data with published values enabled the connectivity of the natural product, which had ...