Chemical communications

Novel chromium (VI) catalyzed oxidation of N-alkylamides to imides with periodic acid

L Xu, S Zhang, ML Trudell

文献索引：Xu, Liang; Zhang, Suhong; Trudell, Mark L. Chemical Communications, 2004 , # 14 p. 1668 - 1669

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被引用次数: 13

摘要

The imide moiety is a commonly occurring structural unit in pharmaceutical agents 1,2 as well as a useful directing group in Michael addition and alkylation reactions. 3,4 Many methods have been developed for the preparation of imides, 5 however, most available methods either employ sophisticated reagents or provide only moderate yields. The direct oxidation of N-alkylamides is the simplest and most straightforward method for preparation of imides. Unfortunately, ...