Phosphorus analogs of. gamma.-aminobutyric acid, a new class of anticonvulsants

LA Cates, VS Li, CC Yakshe, MO Fadeyi…

文献索引：Cates; Li; Yakshe; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 654 - 659

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被引用次数: 18

摘要

A series of phosphorus compounds, designed as analogues of y-aminobutyric acid (GABA) in that they possess a P= O moiety separated by three atoms from an amino or acetamido group, was synthesized and tested by using in vitro GABAA and GABAB receptor binding, GABA uptake assays, and was examined for anticonvulsant activity. Weak GABAB receptor affinity was noted for one agent, whereas six compounds displayed moderate to high ...