Design, synthesis, and crystal structures of 6-alkylidene-2′-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 …
G Bou, E Santillana, A Sheri, A Beceiro…
文献索引：Efimovsky; Rumpf Bulletin de la Societe Chimique de France, 1954 , p. 648
... to catalyze the hydrolysis of the β-lactam bond.(4) In general, serine β-lactamases inactivate β-lactams by a two-step reaction mechanism: Here, E represents the β-lactamase, S is the β-lactam substrate, E:S is the Henri−Michaelis complex, E−S is the acyl-enzyme, and P is the ...
