Journal of medicinal chemistry

Thiazolothiazoles. 3. Synthesis and biological evaluation of functionalized dialkyl derivatives from. gamma.,. gamma.,. gamma.',. gamma.'-tetramethylthiazolo [5, 4-d] …

R Ketcham, S Mah

文献索引：Ketcham,R.; Mah,S. Journal of Medicinal Chemistry, 1971 , vol. 14, p. 743 - 747

全文：HTML全文

被引用次数: 7

摘要

The bis (1, l-dimethylbutyl) derivative was among the most The thiazoloseveral of which have LDbo values and pentobarbital potentiation properties similar to the nitrile. higher homologs was found to be of lower activity. active compounds, thus indicating that a functional group is not essential for depressant activity. thiazole nucleus has been shown to be stable under a variety of standard synthetic procedures.