Recognition of guanine-guanine mismatches by the dimeric form of 2-amino-1, 8-naphthyridine

…, S Sando, H Kumasawa, J Kikuchi, I Saito

文献索引：Nakatani; Sando; Kumasawa; Kikuchi; Saito Journal of the American Chemical Society, 2001 , vol. 123, # 50 p. 12650 - 12657

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被引用次数: 103

摘要

Dimeric 2-amino-1, 8-naphthyridine selectively binds to a GG mismatch with high affinity (K d= 53 nM). We have investigated a binding mechanism of naphthyridine dimer 2 to a GG mismatch by spectroscopic studies, thermodynamic analysis, and structure-activity studies for the thermal stabilization of the mismatch. 1H NMR spectra of a complex of 2 with 9-mer duplex d (CATCGGATG) 2 containing a GG mismatch showed that all hydrogens in two ...