Physicochemical-activity relationships in asymmetrical analogues of methoxychlor

PJ Goodford, AT Hudson, GC Sheppey…

文献索引：Goodford,P.J. et al. Journal of Medicinal Chemistry, 1976 , vol. 19, p. 1239 - 1247

被引用次数: 23

摘要

Compounds of the general formula 2-aryl-2-@-methoxyphenyl)-l, l, l-trichloroethane have been prepared and tested for toxicity toward houseflies, pretreated for 1 h with 2 Fg of piperonyl butoxide. The majority of the compounds synthesized were chosen with the aid of computer programs designed to ensure well-spread sets of minimally correlated physicochemical parameter values. A nonlinear two-dimensional representation was used ...