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Mobile tool for HPLC reaction monitoring

…, DA Rakestraw, C Orella, M McLaughlin…

文献索引:Schafer, Wes A.; Hobbs, Steve; Rehm, Jason; Rakestraw, David A.; Orella, Charles; McLaughlin, Mark; Ge, Zhihong; Welch, Christopher J. Organic Process Research and Development, 2007 , vol. 11, # 5 p. 870 - 876

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被引用次数: 27

摘要

A mobile HPLC reaction monitoring tool consisting of a cart-mounted microfluidic HPLC instrument equipped with a tethered, automated sampling and dilution module is described. Several examples of the use of the instrument for carrying out reaction progress analysis are presented. Reaction aliquot size is typically only a few microliters, allowing extensive sample monitoring from small volume reactions. Reaction quenching is possible, and ...