Synthesis of amides and lactams in supercritical carbon dioxide

…, JM Robinson, JW Tester, RL Danheiser

文献索引：Mak, Xiao Yin; Ciccolini, Rocco P.; Robinson, Julia M.; Tester, Jefferson W.; Danheiser, Rick L. Journal of Organic Chemistry, 2009 , vol. 74, # 24 p. 9381 - 9387

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被引用次数: 24

摘要

Supercritical carbon dioxide can be employed as an environmentally friendly alternative to conventional organic solvents for the synthesis of a variety of carboxylic amides. The addition of amines to ketenes generated in situ via the retro-ene reaction of alkynyl ethers provides amides in good yield, in many cases with ethylene or isobutylene as the only byproducts of the reaction. Reactions with ethoxy alkynes are performed at 120− 130° C, ...