Total synthesis of methyl t??5, c??8, c??11, c??14??and c??5, c??8, c??11, t??14??eicosatetraenoate and of t??2, c??5, c??8, c??11, c??14??eicosapentaenoic acid

GJN Egmond, HJJ Pabon…

文献索引：Egmond,G.J.N. et al. Recueil des Travaux Chimiques des Pays-Bas, 1977 , vol. 96, p. 172 - 175

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被引用次数: 10

摘要

Abstract On the basis of trans-2-hexene-1, 6-diol and trans-2-octenol, both obtained by trans reduction of their acetylenic precursors with sodium in liquid ammonia, trans-5-eicosene-8, 1 1, 14-triynoic acid and trans-14-eicosene-5, 8, 11-triynoic acid were built up by classical methods. Partial hydrogenation and esterification afforded the desired eicosatetraenoates. In addition, reduction of previously described trans-2-eicosene-5, 8, 11, 14-tetraynoic acid ...