Total synthesis of pederin

JC Jewett, VH Rawal

文献索引：Jewett, John C.; Rawal, Viresh H. Angewandte Chemie - International Edition, 2007 , vol. 46, # 34 p. 6502 - 6504

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被引用次数: 58

摘要

Pederin (1, Figure1) has a long and rich history among bioactive natural products.[1] Present in the haemolymph of rove beetles of the genus Paederus,[2] this compound was first obtained in crystalline form in 1919 by Netolitzky and was shown to be a potent vesicant.[3] Pavan and Bo led a massive isolation effort, using 25million field-collected Paederus fuscipes beetles, to secure a sizable quantity of pure pederin,[4] to allow its chemical ...