Tetrahedron

The use of heterocycles for the conformational restriction of biologically active peptoids

DC Horwell, RA Lewthwaite, MC Pritchard, GS Ratcliffe…

文献索引：Horwell, David C.; Lewthwaite, Russell A.; Pritchard, Martyn C.; Ratcliffe, Giles S.; Rubin, J. Ronald Tetrahedron, 1998 , vol. 54, # 18 p. 4591 - 4606

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被引用次数: 27

摘要

A series of piperazinone ring systems have been synthesised as a means of evaluating the effect of conformational restriction on high affinity non-peptide NK1, NK3 and CCK-B receptor ligands. The synthesis of the targeted heterocycles is described along with a discussion of their affinities for their respective receptor types.