Toxic Fluorine Compounds. XVIII. 1 The Synthesis of the Toxic Principle of Dichapetalum toxicarium (18-Fluoro-cis-9-octadecenoic Acid) and Related ω-Fluoro …

REA Dear, FLM Pattison

文献索引：Dear,R.E.A.; Pattison,F.L.M. Journal of the American Chemical Society, 1963 , vol. 85, p. 622 - 626

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被引用次数: 35

摘要

18-Fluoro-cis-9-octadecenoic acid (w-fluoro-oleic acid), synthesized in 36.5% over-all yield utilizing acetylenic intermediates, has been shown to be identical with the toxic principle of Dichapetulum toxicarium. Other w-fluoro unsaturated acids have been prepared, including the isomeric trans-acid (w-fluoro-elaidic acid). The toxicities of all new w-fluoro compounds have been determined; the results, interpreted in terms of previously reported metabolic ...