Library of 1, 4-disubstituted 1, 2, 3-triazole analogs of oxazolidinone RNA-binding agents

G Acquaah-Harrison, S Zhou, JV Hines…

文献索引：Acquaah-Harrison, George; Zhou, Shu; Hines, Jennifer V.; Bergmeier, Stephen C. Journal of Combinatorial Chemistry, 2010 , vol. 12, # 4 p. 491 - 496

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被引用次数: 18

摘要

The design and synthesis of small molecules that target RNA is immensely important in antibacterial therapy. We had previously reported on the RNA binding of a series of 4, 5- disubstituted 2-oxazolidinones that bind to a highly conserved bulge region of bacterial RNA. This biological target T box antitermination system, which is found mainly in Gram- positive bacteria, regulates the expression of several amino acid related genes. In an ...