Combination of 2-(hydroxymethyl)-5-oxazolinylpyridine 16a with lariat ethers 21 and 23 generated chiral 6-methylnicotinic oxazoline lariat ethers 22 and 24, respectively. Chiral lariat ether 24b by stereoselective metal-directed addition of methylmagnesium bromide was converted to the corresponding enantiomerically enriched N-magnesio-l, 4-dihydropyridine 26. Lariat 26 and the nonlariat analogue 31 both reduced a, a, a-trifluoroacetophenone in ...
