Regioselective synthesis of 3-(methylthio) phenols by formal [3+ 3]-cyclocondensations of 3-oxo-bis (methylthio) ketenacetals with 1, 3-bis (trimethylsilyloxy)-1, 3- …
…, F Bendrath, T Trabhardt, A Villinger, C Fischer…
The cyclization of 1, 3-bis (trimethylsilyloxy)-1, 3-butadienes with 3-oxo-bis (methylthio) ketenacetals afforded 3-(methylthio) phenols containing an acyl or ester substituent located at position 2. The cyclization of free 1, 3-dicarbonyl dianions with 3-oxo-bis (methylthio) ketenacetals resulted in the formation of regioisomeric products containing an acyl group located at position 6.
