Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke

…, JL Diaz, B Hengerer, J Herrmann, KG Jahangiri…

文献索引：Linton, Steven D.; Aja, Teresa; Allegrini, Peter R.; Deckwerth, Thomas L.; Diaz, Jose-Luis; Hengerer, Bastian; Herrmann, Julia; Jahangiri, Kathy G.; Kallen, Joerg; Karanewsky, Donald S.; Meduna, Steven P.; Nalley, Kip; Robinson, Edward D.; Roggo, Silvio; Rovelli, Giorgio; Sauter, Andre; Sayers, Robert O.; Schmitz, Albert; Smidt, Robert; Ternansky, Robert J.; Tomaselli, Kevin J.; Ullman, Brett R.; Wiessner, Christoph; Wu, Joe C. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2685 - 2691

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被引用次数: 23

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein. ... Structural modifications ...