Tetrahedron letters

Synthesis of arylpiperazines via palladium-catalysed aromatic amination reactions of bromoarenes with N-tert-butoxycarbonylpiperazine

F Kerrigan, C Martin, GH Thomas

文献索引：Kerrigan, Frank; Martin, Claire; Thomas, Gerard H. Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2219 - 2222

全文：HTML全文

被引用次数: 48

摘要

Reaction of a series of bicyclic bromoarenes with N-tert-butoxycarbonylpiperazine (N-Boc- piperazine) under palladium-catalysed coupling conditions followed by routine removal of the Boc group with trifluoroacetic acid in dichloromethane gave the corresponding arylpiperazines in moderate to good yield.